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Nearly one half of all pregnancies in the United States are unplanned. An unintended pregnancy can have serious health consequences in women with chronic medical conditions. Certain diseases can be worsened by pregnancy or are associated with adverse outcomes. Moreover, medications used to treat many chronic conditions are potentially teratogenic.
SORT: KEY RECOMMENDATIONS FOR PRACTICE Clinical recommendation Evidence rating References
OCPs may be considered in healthy, nonsmoking women older than 35 years if there are no other contraindications to combined hormonal contraceptives.
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OCPs may be considered in women who have migraine headaches without aura if they do not have focal neurologic symptoms, do not smoke, are younger than 35 years, and are otherwise healthy.
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OCPs appear to be safe in women with stable or inactive systemic lupus erythematosus who do not have antiphospholipid antibodies.
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Injectable long-acting progestin (depot medroxyprogesterone acetate [Depo-Provera]) is an appropriate contraceptive option for women with sickle cell disease and has been shown to reduce painful crises.
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SORT: KEY RECOMMENDATIONS FOR PRACTICE Clinical recommendation Evidence rating References
OCPs may be considered in healthy, nonsmoking women older than 35 years if there are no other contraindications to combined hormonal contraceptives.
C
, , ,
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OCPs appear to be safe in women with stable or inactive systemic lupus erythematosus who do not have antiphospholipid antibodies.
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Injectable long-acting progestin (depot medroxyprogesterone acetate [Depo-Provera]) is an appropriate contraceptive option for women with sickle cell disease and has been shown to reduce painful crises.
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A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to .
Despite this, women with comorbidities may not receive adequate counseling on contraceptive methods. For example, in a study at an urban epilepsy center, 50 percent of women experienced unplanned pregnancies. Almost 17 percent of these women were taking antiepileptic drugs that reduce the effectiveness of hormonal contraceptives. Additionally, women with diabetes mellitus rarely receive contraceptive counseling during ambulatory visits, even though poor preconception glycemic control can be associated with adverse outcomes.
In 2006, the American College of Obstetricians and Gynecologists (ACOG) published guidelines for the use of hormonal contraceptives in women with comorbidities. Since its publication, new contraceptive products have been approved by the U.S. Food and Drug Administration, and new data about the risks of the contraceptive patch (Ortho Evra) and the long-acting injectable progestin, depot medroxyprogesterone acetate (Depo-Provera), have emerged.
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Daily pill
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Immediate
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3 to 8
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Progestin-only
Norethindrone (Micronor) [
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